Quality of Traditional Chinese Medicine Preparations
As for the quality control of solid preparations, weight difference, mixing average and tablet strength are related to powder operation, while disintegration time, dissolution and bioavailability are related to powder properties of various materials in drug prescriptions. Due to the characteristics of ultra-fine powder of traditional Chinese medicine, there are still many influencing factors in the technical process of ultra-fine grinder. It is difficult for the same equipment and the same grinding process to reach the request of the same ultra-fine powder. In fact, not all drugs are the smaller the particle size, the better, we should confirm the best particle size of single herbs and compound preparations through experiments.
Due to its remarkable technical advantages and huge economic potential, powder direct tableting technology has become the focus and trend of pharmaceutical enterprises, especially large foreign pharmaceutical enterprises, in reforming their consumption line. The biggest obstacle to the universal application of powder direct pressing technology is the powder control, consumption efficiency and the application rate of consumption line of raw materials and accessories themselves. After micronization of medicinal materials, some unfavorable factors will be brought to pharmaceutical operations, such as dust flying, powder gathering and activity problems.
Ultrafine crushing of traditional Chinese medicine is not the finer the better. It is necessary to control the physical indexes of powder according to the requirements of customers or processes, such as particle size and dispersion, specific surface area of particles, loose density and knock density, activity, disintegration and so on.
Technical Characteristics and Equipment of Ultrafine Crusher
In the practice of industrial consumption, traditional methods are often used to stop crushing and pretreatment of medicinal materials. After screening, the medicinal materials are further superfine crushed to reach the required size specifications (grading). The application of ultra-fine crusher technology of traditional Chinese medicine has brought about the transformation and development of traditional Chinese medicine dosage forms and broadened the dosage forms of crude drugs.
The key to the ultra-fine grinding process is to determine the appropriate grinding force field according to the physical characteristics of the crude drug, so as to select the most effective ultra-fine grinding equipment. At present, the main methods of ultra-fine crushing of traditional Chinese medicine are mechanical crushing, vibration crushing and airflow crushing. There are many kinds of domestic ultra-fine crushing consuming industrial equipment sales, including vibration crusher, mechanical shear crusher, cryogenic crusher and airflow crusher. Later, they are widely used in pharmaceutical industry, while airflow crusher uses fluidized bed airflow ultrafine crusher. The most widely used.
Mechanical ultra-fine comminution can be divided into dry comminution and wet comminution. According to the different principles of the comminution force, dry comminution can be divided into airflow, high frequency vibration, rotating ball (rod) grinding, hammering and self-grinding. The main wet comminution methods are colloid mill and homogenizer.
Modern ultra-fine grinder technology is to stop the micro-combination of drugs, and make full use of micro-grinding, compounding, refinement, surface modification and particle design technology to achieve the highest level of drugs. In this regard, the technology space for discussion and application is very broad. Deepening research and application of this technology will be a new technological growth point and a new economic growth point for TCM. The pause in the field of particles and nanoparticles in foreign countries is very rapid. The appearance of controlled-release drugs is the typical application of ultra-fine grinding technology, which can broaden the dosage forms of crude drugs and promote the application of advanced preparations technology in this "crude drugs" dosage form. In a word, the application of ultra-fine grinder technology in traditional Chinese medicine preparation will make the development of traditional Chinese medicine enter a new stage.