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中药材低温粉碎机优势特点介绍

1、应用高强度的振动,使物料在磨筒内遭到高速度的撞击、商讨,使物料在极短时间内获得平均的粉碎和混合效果。其优点是介质填充率和单位时间内的作用次数高、能耗低。经过调理振幅、振动频率、介质类型等,可加工不同粒度的产品。
1. Applying high-intensity vibration, the material is impacted and discussed at high speed in the grinding barrel, so that the material can get average grinding and mixing effect in a very short time. Its advantages are high filling rate of medium, high action times per unit time and low energy consumption. After adjusting the amplitude, vibration frequency and medium type, the products with different particle sizes can be processed.
2、在超微粉碎过程中,可在低温状态下停止,并且粉碎速度快,有利于保存不耐高温的生物活性成分及各种营养成分,从而进步药效,因而超微粉碎技术也能够适用于含芳香性挥发成分药材。超微粉碎可依据不同药材的需求,采用中温、低温及超低温粉碎。对纤维状、高韧性、高硬度或具有一定水分的药物均顺应,特别对质地致密的动物贝壳类、骨类药材和矿物类药才更具有优越性。此项技术既可用于干法粉碎,也适用于湿法粉碎,因而应用范围广。
2. In the process of Ultra-micro comminution, it can stop at low temperature, and the comminution speed is fast. It is beneficial to preserve the bioactive ingredients and various nutrients which are not resistant to high temperature, thus improving the pharmacodynamics. Therefore, ultra-micro comminution technology can also be applied to medicinal materials containing aromatic volatile ingredients. Ultra-micro grinding can be done at medium, low and ultra-low temperatures according to the needs of different medicinal materials. It is suitable for medicines with fibrous, high toughness, high hardness or certain moisture content, especially for animal shells, bone medicines and mineral medicines with compact texture. This technology can be used not only in dry crushing but also in wet crushing, so it has a wide range of applications.
中药低温粉碎机
3、进步药物的溶出速度和溶出量。实考证明,中药有效成分的溶出速度、溶出量与粉碎产品颗粒的特性亲密相关。溶出速率与药物的外表积成正比,等量的药物,其粒子越小、外表积越大,越有利于药物的溶出和吸收。
3. Improve the dissolution rate and quantity of drugs. It has been proved that the dissolution rate and amount of the active ingredients of traditional Chinese medicine are closely related to the characteristics of crushed product particles. The dissolution rate is proportional to the surface area of the drug. The smaller the particle size and the larger the surface area of the drug, the better the dissolution and absorption of the drug.
4、细胞级粉碎,有利于进步药效。中药材中的有效成分通常散布于细胞内与细胞间质,而以细胞内为主。存在于细胞内的有效成分只要透过细胞壁及细胞膜释放出来,才干被小肠壁吸收而发挥作用。超微粉碎正是以植物类药材细胞破壁为目的的粉碎作业,细胞经破壁后,细胞内的有效成分充沛暴显露来,药物的释放速度及释放量会大幅度进步。经超微粉碎的药物粒径很小,破壁率高,有效成分在进入体内后,可溶性成分疾速溶解,即便溶解性差的成分也因超微粉具有较大的附着力而粘附在粘膜上,因此有利于药物的吸收。
4. Cell-level comminution is conducive to the improvement of pharmacodynamics. The active ingredients in traditional Chinese medicines are usually dispersed in cells and interstitial cells, but mainly in cells. Effective components in cells can only be absorbed by the small intestinal wall if they are released through the cell wall and cell membrane. Ultrafine comminution is the comminution of plant medicinal materials for the purpose of cell wall breaking. After cell wall breaking, the effective components of cells are abundantly exposed, and the release rate and quantity of drugs will be greatly improved. After ultrafine grinding, the drug particle size is very small and the breakage rate is high. After the effective ingredients enter the body, the soluble ingredients quickly dissolve. Even the components with poor solubility are adhering to the mucosa because of the strong adhesion of ultrafine powder, which is beneficial to the absorption of drugs.
5、改善卫生条件,进步产品卫生学程度。 超微粉碎是在封锁系统下停止粉碎的,既防止了微粉污染四周环境,又可避免空气中的灰尘污染产品。故在食品及医疗保健品中运用该技术,可使微生物含量及灰尘得以控制,契合药品消费的GMP请求。
5. Improve hygienic conditions and product hygiene. Ultra-fine comminution is stopped under the blockade system, which not only prevents micro-powder from polluting the surrounding environment, but also avoids dust pollution in the air. Therefore, the application of this technology in food and health care products can control the microbial content and dust, and meet the GMP requirements of drug consumption.
6、完善中药固体制剂工艺,改善剂型  中药丸、散剂占固体类制剂相当大的比例,传统的加工技术使药物粒度多在125~180μm之间,不利于有效成分的充沛吸收,一些外用散剂以至会产生部分刺激作用。但引入超微粉碎技术,可使药物粒子到达10μm,以至更小,可明显增加内服制剂在体内的溶解吸收水平,并有可能用较小剂量到达原方的疗效。
6. Improving the technology of solid preparations of traditional Chinese medicine, improving the proportion of pills and powder in solid preparations. Traditional processing technology makes the granularity of drugs more than 125-180 micron, which is not conducive to the full absorption of active ingredients. Some external dispersions even have some stimulating effects. However, by introducing ultrafine comminution technology, the drug particles can reach 10 micrometers or even smaller, which can significantly increase the dissolution and absorption level of oral preparations in vivo, and it is possible to reach the curative effect of the original prescription with a small dose.
7、有利于研制超细粉体化饮片,促进产业化。对工业化提取工艺不合适的某些中药,如矿物药、贵重药、有效成分易受湿热毁坏的药物、有效成分不明的药物等,可粉碎后入药,但常规粉碎工艺制得的产品起效慢、生物应用度不高;而超细粉体工艺制得的产品起效疾速、生物应用度高,能进步疗效、降低不良反响、减少服用剂量、节约药材。
7. It is conducive to the development of ultra-fine powder pieces and the promotion of industrialization. Some traditional Chinese medicines which are not suitable for industrial extraction process, such as mineral drugs, precious drugs, medicines whose active ingredients are easily destroyed by dampness and heat, medicines whose active ingredients are unknown, can be crushed and then used as medicines, but the products made by conventional crushing process have slow onset and low biological application, while the products made by ultra-fine powder process have rapid onset and high biological application, which can improve curative effect and reduce adverse effects. Respond, reduce dosage and save medicinal materials.
8、开发中药新剂型。 经过超细化关于鹿茸、珍珠、海马、冬虫夏草等宝贵中药材均可直接制成中药口服散剂、胶囊剂、微囊、β-环糊精包含物及膏剂等。在冲剂、胶囊剂、片剂、膜剂等固体制剂中,依据处方性质,在制备工艺的某些环节引入超微粉碎技术,亦可在溶解度、崩解度、吸收率、附着力及生物应用度方面改善其质量。
8. Developing new dosage forms of traditional Chinese medicine. The precious traditional Chinese medicines such as pilose antler, pearl, hippocampus and Cordyceps sinensis can be directly made into oral powder, capsule, microcapsule, inclusion of beta-cyclodextrin and paste of traditional Chinese medicines. In solid preparations such as granules, capsules, tablets and membranes, ultrafine comminution technology is introduced in some links of the preparation process according to the prescription properties, which can also improve the quality of granules in terms of solubility, disintegration, absorptivity, adhesion and biological applicability.

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