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中药超细粉碎技术的应该朝哪些方面发展?

针对传统工业类粉碎技术对制备超细中药中存在的问题,如对坚韧纤维加工难,过程温升、成份挥发、磨损污染、聚会、氧化等,将来中药超细粉碎技术的开展方向如下:
In view of the problems existing in the preparation of ultra-fine traditional Chinese medicine by traditional industrial grinding technology, such as the difficulty in processing tough fibers, temperature rise, volatilization of components, abrasion pollution, gathering and oxidation, the development direction of ultra-fine grinding technology of traditional Chinese medicine in the future is as follows:
(1)低温(<0℃)和超低温(-150℃的液氮)技术引入机械冲击式、气流粉碎机、振动磨等设备,显著的效果有:
(1) Low temperature (< 0 C) and ultra-low temperature (- 150 C) liquid nitrogen) technology are introduced into mechanical impact, air flow mill, vibration mill and other equipment. The remarkable results are as follows:
使坚韧性中药材变成易粉碎的脆性体,大大进步了粉碎效率。
The crushing efficiency is greatly improved by transforming the tough Chinese medicinal materials into brittle bodies which are easy to crush.
有效避免加工过程成份挥发或氧化。
Effectively avoid volatilization or oxidation of components during processing.
改善产品分散性。
Improve product dispersion.
但加工本钱增加。
But the processing cost increased.
(2)气流粉碎机引入剪切力,如循环管式气流粉碎上装置可调速的旋转冲击剪靶,可不加低温技术就可能粉碎坚韧纤维中草药材。
中药超细粉碎机
(2) The introduction of shear force by air-flow mill, such as rotating impact shear target with adjustable speed on circulating tube air-flow mill, may crush tough fibre Chinese herbal medicines without cryogenic technology.
(3)粒径分段粉碎集成技术,特别对坚韧纤维植物药,先粗粉碎(剪切,在枯燥阶段),再细粉碎(75-100μm),后超细粉碎(l-10μm),这种技术组合,能充沛发挥不同粉碎办法的优势,在不附加低温技术条件下进步粉碎效率和对原药适用范围。
(3) Particle size segmented grinding integration technology, especially for tough fibre plant medicine, first crushing (shearing, in the dry stage), then fine grinding (75-100 um), and finally ultra-fine grinding (l-10 um). This technology combination can fully play the advantages of different grinding methods and improve grinding efficiency without adding low-temperature technology. And the scope of application of the original drug.
(4)将颗粒外表改性技术引入粉碎加工过程,如添加分散剂、填料、包覆、颗粒复合等,有效避免聚会、挥发、氧化、制备新的复合制剂,进步药效,使中药制剂也具备控释缓释靶向等功用。
(4) Introducing the technology of particle surface modification into the crushing process, such as adding dispersant, filler, coating, particle compounding, effectively avoiding gathering, volatilization, oxidation, preparation of new composite preparations, improving the pharmacodynamics, so that traditional Chinese medicine preparations also have the functions of controlled release, slow release and targeting.
(5)采用高强韧性耐磨陶瓷资料或生物相容性的耐磨高分子资料替代粉碎机内壁、磨介和内衬的合金资料,不只进步加工机寿命和降低维持本钱,同时也避免合金的污染。
(5) Using high strength and toughness wear-resisting ceramic materials or biocompatibility wear-resisting polymer materials to replace the alloy materials of crusher inner wall, grinding medium and lining not only improves the service life of the machine and reduces the maintenance cost, but also avoids the pollution of the alloy.
(6)契合GMP标准和平安的一体化封锁的加工系统。这种工程系统的呈现,有利于超细中药规范化的施行。系统集原药予处置(清洗、枯燥或低温处置),粉碎、分级、外表改性,产品检测,包装于一体的密闭维护机组中。
(6) Processing system conforming to GMP standard and safe and integrated blockade. The presentation of this engineering system is conducive to the standardization of ultra-fine traditional Chinese medicine. The system integrates the original drug disposal (cleaning, drying or low temperature disposal), crushing, grading, surface modification, product testing, packaging in an integrated airtight maintenance unit.
总之,由于不同的药材其组织构造不同,所含成分不同,对粉碎度的请求不同,剂型不同、给药途径不同,也请求不同的细度,应依据详细请求和目的从药效、平安性、稳定性等方面综合思索,肯定佳超细粉碎设备和工艺。
In a word, because different medicinal materials have different tissue structure, different components, different requests for grinding degree, different dosage forms, different ways of administration, and different fineness, we should think comprehensively from the aspects of pharmacodynamics, safety and stability according to detailed requests and purposes, and affirm the best ultra-fine grinding equipment and technology.

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