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超微粉碎对中药粉体性质带来的影响及存在的问题

1.对中药粉体比外表积、孔隙度及活动性的影响。在研讨中发现,随着粉体粒径的减小,骨碎补、三七等中药粉体的比外表积和孔隙度增加,休止角和紧缩指数增大,标明比外表积和孔隙度均与粒度成正相关,活动性与粒度成负相关。
1. The influence on the specific surface area, porosity and activity of Chinese medicine powder. In the study, it was found that with the decrease of particle size, the specific surface area and porosity of traditional Chinese medicine powder such as Rhizoma Drynariae, Panax Notoginseng increased, the angle of repose and compaction index increased, indicating that specific surface area and porosity were positively correlated with particle size, and activity was negatively correlated with particle size.
2.对中药粉体中有效成分含量的影响。研讨发现,随着粉体粒径的减小,当归粉体中阿魏酸的含量显著降低,这可能是由于阿魏酸的稳定性较差; 冰片中龙脑和异龙脑含量显著降低,这可能是由于冰片中的成分易挥发。其他血竭、大黄等大局部中药粉体中有效成分的含量与细粉相比,均未发作明显变化。因而,对含有不稳定和挥发性成分的药材,采用超微粉碎应谨慎,在粉碎时,应控制粉碎时间,或采用低温粉碎以减少其有效成分的损失和挥发。
2. The effect on the content of active ingredients in Chinese medicine powder. It was found that the content of ferulic acid in Angelica sinensis powder decreased significantly with the decrease of powder size, which may be due to the poor stability of ferulic acid; borneol and isoborneol content in borneol decreased significantly, which may be due to the volatility of the components in borneol. Compared with fine powder, the content of active ingredients in most of the traditional Chinese medicine powders, such as Dragon's Blood and Rhubarb, did not change significantly. Therefore, for medicines containing unstable and volatile components, the use of ultrafine grinding should be cautious. When grinding, the grinding time should be controlled, or low-temperature grinding should be used to reduce the loss and volatilization of their effective components.
3.对中药粉体体内、外稳定性的影响。从稳定性角度看,普通以为药物经超微粉碎后粒度减小,粒子外表会愈加容易吸附水、空气和带有电荷,从而增加寄存难度,使其稳定性变差。但有研讨标明,在某些环境下,如光照条件、人工胃液中,超微粉碎不只没有加剧粉体中有效成分的物理或化学不稳定性,并且对粉体的稳定性具有一定维护作用。
中药低温粉碎机
3. The effect on the stability of TCM powder in vivo and in vitro. From the point of view of stability, it is generally believed that the particle size decreases after ultrafine comminution, and the surface of the particles will be more easily absorbed by water, air and charges, thus increasing the difficulty of storage and making its stability worse. However, some studies have shown that in some environments, such as illumination and artificial gastric juice, ultrafine grinding not only does not aggravate the physical or chemical instability of the active ingredients in the powder, but also maintains the stability of the powder.
4.对中药粉体质量、外观的影响。停止超微粉碎后的中药粉体,其粉末细腻,色泽分歧,使其平均性有所进步,并改动了传统粉碎办法粉碎后中药粉末质地粗糙、纤维与粉末别离平均性差、花斑较多的现象,进步了药物质量。并且,停止超微粉碎后的中药粉体更易于成型,便于制造片剂、胶囊等。
4. The influence on the quality and appearance of Chinese medicine powder. After stopping ultrafine comminution, the powder of traditional Chinese medicine powder is exquisite and different in color and luster, which improves its average quality. The traditional comminution method has changed the phenomenon of rough texture, poor average separation between fiber and powder, and more spots, which improves the quality of medicine. Moreover, the powder of traditional Chinese medicine after stopping ultrafine comminution is easier to form, and is easy to manufacture tablets, capsules, etc.
存在问题
Existing problems
超微粉碎为植物药提取的前处置又提供了一个新办法,为高效的运用中药材提供了一个新的研讨方向。但超微粉碎技术也存在一些问题:
Ultrafine comminution provides a new method for the pre-disposal of plant medicines, and provides a new research direction for the efficient use of traditional Chinese medicines. But there are also some problems in ultra-fine comminution technology:
1.不是一切的中药都合适超微粉碎。将超微粉碎技术应用于中药根底研讨时,只要肯定详细种类的最适粒度,才干发挥其优势。如超微粉碎药物粒度固然能够尽量减小,而溶解度和溶解速度却不会无限制地增大,粒度小到一定水平时外表能要素就显显露来,而且过细的粒子外表会吸附空气并带有电荷,从而影响药物吸收,增加药物寄存难度。
1. Not all Chinese medicines are suitable for ultrafine grinding. The application of ultrafine grinding technology in the study of the root of traditional Chinese medicine can bring its advantages into full play as long as the optimum particle size of the detailed species is affirmed. For example, the particle size of ultrafine crushing drugs can be reduced as much as possible, but the solubility and dissolution rate will not increase indefinitely. When the particle size is small enough to a certain level, the apparent energy elements will be revealed. Moreover, the appearance of ultrafine particles will absorb air and carry charges, thus affecting drug absorption and increasing the difficulty of drug storage.
2.中药超微粉碎技术缺乏规范化、标准化的研讨。近几年,中药超微粉碎技术可进步药效的理论正逐渐被普遍认可,但要到达产业化和在临床上普遍应用,需求有相关成熟的规范来支持。消费工艺规范,检验和质量规范,超微粉碎粒径划定范围、目数规范等应尽快研讨并逐渐加以完善,以便用于指导消费。随着科学技术的开展和根底研讨力度的加大,置信超微粉碎技术在中药制剂范畴中所面临的这些问题会得到处理。
2. The ultrafine comminution technology of traditional Chinese medicine is lack of standardization. In recent years, the theory that ultra-fine comminution technology of traditional Chinese medicine can improve pharmacodynamics is gradually accepted, but to achieve industrialization and clinical application, there is a need for mature norms to support. Consumption process specifications, inspection and quality specifications, the delimitation scope of ultrafine grinding particle size, and the specification of the number of items should be discussed and improved as soon as possible so as to guide consumption. With the development of science and technology and the intensification of basic research, it is believed that these problems faced by ultrafine grinding technology in the field of traditional Chinese medicine preparations will be dealt with.
3.中药微粉化后的平安性研讨工作有待进一步展开。中药微粉粒径很小, 能否会黏附在胃肠黏膜上影响胃肠功用? 中药细胞壁毁坏后, 细胞内的活性成分能否会发作化学变化而在肾、肝、血液、心血管、神经系统等部位产生不良影响? 可见, 理论和理论研
3. The study on the safety of micronized Chinese medicines needs to be further carried out. Can the micropowder of traditional Chinese medicine adhere to gastrointestinal mucosa and affect gastrointestinal function? After the cell wall of traditional Chinese medicine is destroyed, can the active ingredients in cells undergo chemical changes and have adverse effects on kidney, liver, blood, cardiovascular, nervous system and so on? It can be seen that theoretical and theoretical research has been carried out.
以上的精彩内容由中药低温粉碎机进行编写发布,如有更多的问题,欢迎致电或者是在站内进行留言,我们会对您提出的问题进行及时的解答。
The above wonderful content is compiled and published by the low-temperature crusher of traditional Chinese medicine. If you have more questions, please call or leave a message at http://www.aswjc.com. We will answer your questions in time.

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